In early 2006, Duran Duran covered John Lennon's song "Instant Karma" for the Make Some Noise campaign sponsored by Amnesty International to commemorate the 25th anniversary of Lennon's death. The band played the song live on a few tour dates. Their version featured a heavier rhythm section than Lennon's version, especially the bass. Early 2006 saw the band performing at two high profile events - the Nobel Prize Awards and the 2006 Winter Olympics in Turin, Italy. They also appeared at the Sporting Summer Festival in Monte Carlo. On October 25th, 2006, Andy Taylor again parted ways with Duran Duran, leaving the band for the second time. In an official announcement on their website, Duran Duran pledged to continue with four members, stating that an "unworkable gulf" had developed between them and Andy and that "we can no longer effectively function together". For the remaining 2006 tour dates, Dominic Brown would stand in as guitarist. Dominic Brown had previously stood in as Duran Duran's guitarist during Andy's absence in November and December 2004 and again for three weeks on their American arena tour during March 2005.

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